Langerhanszell-Histiozytose - DocCheck Flexikon
WEB21. März 2024 · Definition. Der Begriff Langerhanszell-Histiozytose, kurz LCH oder LZH, umfasst eine Gruppe von Erkrankungen, die durch die klonale Proliferation von sogenannten Langerhans-Zellen gekennzeichnet sind. Diese Zellen infiltirieren verschiedene Geweben und bilden dort Granulome. Es handelt sich um den …
Langerhans cell histiocytosis - Wikipedia
WEBLangerhans cell histiocytosis (LCH) is an abnormal clonal proliferation of Langerhans cells, abnormal cells deriving from bone marrow and capable of migrating from skin to lymph nodes. Symptoms range from isolated bone lesions to multisystem disease . [1]
Langerhans Cell Histiocytosis - StatPearls - NCBI Bookshelf
WEB18. Apr. 2024 · Langerhans cell histiocytosis (LCH) is a neoplastic disorder that arises from an expansion of early myeloid cells in the bone marrow compartment, most commonly due to a clonal mutation in the RAS/MAP Kinase signaling pathway. This process results in the dissemination of CD1a and CD207 (Langerin) positive cells, manifesting as a …
Pathology Outlines - Langerhans cell histiocytosis
WEB2. März 2020 · Langerhans cell histiocytosis is a clonal proliferation of cells that morphologically and immunophenotypically resemble Langerhans cells. More common in childhood (1 - 3 years old) and involves nodal and extranodal sites (most common site is bone) Lesional cells show prominent nuclear grooves with admixed eosinophils and are …
ランゲルハンス細胞組織球症（LCH）│小児がん | 国立成育医療研 …
WEBランゲルハンス細胞組織球症（ Langerhans cell histiocytosis:LCH）とは 病態・発症頻度・原因. ランゲルハンス細胞は、枝を伸ばしたような形の樹状細胞のひとつで、組織球に分類されます。皮膚など外界と接する部位に存在しており、病源体などを認識して周囲の ...
Langerhans-Cell Histiocytosis | New England Journal of Medicine
WEB29. Aug. 2018 · Langerhans-cell histiocytosis (LCH), the most common histiocytic disorder, encompasses conditions characterized by aberrant function and differentiation or proliferation of cells of the...
Langerhans cell histiocytosis | Radiology Reference Article ...
WEB20. Jan. 2023 · Langerhans cell histiocytosis is due to uncontrolled monoclonal proliferation of Langerhans cells (distinctive cells of monocyte-macrophage lineage) and should be considered a malignancy although its biological behavior is very variable 1,3. An immune-mediated mechanism has been postulated. This proliferation is accompanied by …
Langerhans cell histiocytosis - American Society of Hematology
WEB16. Apr. 2020 · Langerhans cell histiocytosis (LCH) is a disease characterized by clonal expansion of myeloid precursors that differentiate into CD1a + /CD207 + in lesions. It presents at all ages with various degrees of systemic involvement, and although cure rates are high, severe long-term neurological or endocrine complications may affect quality of …
Langerhans Cell Histiocytosis Treatment - NCI - National Cancer Institute
WEB29. März 2024 · Langerhans Cell Histiocytosis (LCH) treatment depends on where it is found in the body and whether the LCH is low or high risk. Treatment can include chemotherapy, surgery, radiation therapy, photodynamic therapy, immunotherapy, and targeted therapy. Learn more in this expert-reviewed summary.
Langerhans Cell Histiocytosis: Version 2021 - PMC - National …
WEBLangerhans cell histiocytosis (LCH), the most common histiocytic disorder in children, is the focus of this article. We will also briefly describe features related disorders: juvenile xanthogranuloma (JXG), Erdheim–Chester disease (ECD), and sinus histiocytosis with massive lymphadenopathy (SHML), also called Rosai-Dorfman disease (RDD). Table 1.
Weiter zum Inhalt