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- Leydig cell tumors arise from the interstitial cells of Leydig adjacent to the seminiferous tubules. Clinical presentation Leydig cell tumors of the testis may present with serum hormonal imbalance (~30%). Virilization (including precocious puberty) may occur. Hyperestrogenism may also occur and patients may demonstrate gynecomastia.pacs.de/term/leydig-zell-tumor-des-hodens
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