Glucokinase - Wikipedia
WebGlucokinase in beta cells serves as a glucose sensor, amplifying insulin secretion as blood glucose rises. In the pancreatic beta-cell, glucokinase is a key regulator enzyme. Glucokinase is very important in the regulation of insulin secretion and has been known as the pancreatic beta-cell sensor.
Glucokinase - DocCheck Flexikon
WebJul 19, 2023 · 1 Definition. 2 Funktion. 3 Enzymkinetik. 4 Glucokinase-Regulatorprotein (GkRP) Definition. Die Glucokinase ist ein Enzym, das in Hepatozyten und in den Betazellen des Pankreas den ersten enzymatischen Schritt der Glycolyse übernimmt.
The Central Role of Glucokinase in Glucose Homeostasis: A …
WebMar 6, 2019 · It is hypothesized that glucokinase (GCK) is the glucose sensor not only for regulation of insulin release by pancreatic β-cells, but also for the rest of the cells that contribute to glucose homeostasis in mammals. This includes other cells in endocrine pancreas (α- and δ-cells), adrenal gland, glucose sensitive neurons, entero ...
Molecular and Cellular Regulation of Human Glucokinase - PMC
WebMar 3, 2019 · Glucose metabolism in humans is tightly controlled by the activity of glucokinase (GCK). GCK is predominantly produced in the pancreas, where it catalyzes the rate-limiting step of insulin secretion, and in hepatocytes, where it participates in glycogen synthesis. A multitude of disease-causing mutations within the gck gene have been ...
Glucokinase activity in diabetes: too much of a good thing?
WebGlucokinase is a key beta-cell glucose-sensor that confers the unique ability to respond to plasma glucose levels over a wide range and is essential for insulin secretion. However, this very ability may be detrimental in chronic hyperglycaemia, as the beta-cell has no way to limit glucose metabolism. This leads to detrimental changes in the ...
Glucokinase as an emerging anti-diabetes target and recent …
WebJan 24, 2022 · The currently available clinical data suggest that GKA can effectively control the levels of HbA1c in patients with type 2 diabetes and can be used to treat this disease. In addition, GKA were well tolerated by patients and associated with a low risk of developing minor adverse effects ( p > 0.05).
Assessing the potential of glucokinase activators in diabetes
WebApr 17, 2009 · Key Points. The glucose-phosphorylating enzyme glucokinase has a crucial role in glucose homeostasis as 'glucose sensor' of the insulin-producing pancreatic β-cells and as a...
Insights into Mechanism of Glucokinase Activation - Journal of ...
WebHuman glucokinase (GK) is a principal regulating sensor of plasma glucose levels. Mutations that inactivate GK are linked to diabetes, and mutations that activate it are associated with hypoglycemia.
Molecular and cellular regulation of human glucokinase
WebMar 15, 2019 · PMID: 30641049. PMCID: PMC6377845. DOI: 10.1016/j.abb.2019.01.011. Abstract. Glucose metabolism in humans is tightly controlled by the activity of glucokinase (GCK). GCK is predominantly produced in the pancreas, where it catalyzes the rate-limiting step of insulin secretion, and in the liver, where it participates in glycogen synthesis.
The manifold roles of protein S-nitrosylation in the life of insulin ...
WebNov 17, 2021 · Metrics. Abstract. Insulin, which is released by pancreatic islet β-cells in response to elevated levels of glucose in the blood, is a critical regulator of metabolism. Insulin triggers the...
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